Treatment of Cisplatin Ototoxicity by Anti-oxidant Drugs.
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چکیده
منابع مشابه
Coenzyme Q10 plus Multivitamin Treatment Prevents Cisplatin Ototoxicity in Rats
Cisplatin (Cpt) is known to induce a high level of oxidative stress, resulting in an increase of reactive oxygen species damaging the inner ear and causing hearing loss at high frequencies. Studies on animal models show that antioxidants may lower Cpt-induced ototoxicity. The aim of this study is to evaluate the ototoxic effects of two different protocols of Cpt administration in a Sprague-Dawl...
متن کاملThe effect of lycopene on the ototoxicity induced by cisplatin.
UNLABELLED Background/aim: To determine the efficacy of lycopene, which is considered an antioxidant agent, in decreasing the cochlear damage induced by cisplatin. MATERIALS AND METHODS A total of 38 rats were randomized into 4 groups: control, cisplatin, cisplatin + lycopene, and lycopene-treated groups. In all groups, the distortion-product otoacoustic emission measurements were performed o...
متن کاملThe Effect of Dexpanthenol on Ototoxicity Induced by Cisplatin
OBJECTIVES This study was aimed to investigate the protective effects of dexpanthenol (Dxp) on against cisplatin-induced ototoxicity. METHODS To examine this effect, distortion product otoacoustic emissions (DPOAEs) measurements and serum levels of oxidative and antioxidant status (including malondialdehyde, superoxide dismutase, catalase, glutathione, glutathione peroxidase, total oxidant st...
متن کامل[Genetic background of cisplatin induced ototoxicity].
BACKGROUND Cisplatin induced ototoxicity is a serious adverse effect of cisplatin therapy. Cisplatin induced ototoxicity shows significant interindividual variability. This variability is probably based on genetic background. Recent papers describe association of cisplatin ototoxicity with allelic variants of glutathion-S-transferase coding genes. PATIENTS AND METHODS We have analyzed 55 pati...
متن کاملMechanisms of Cisplatin-Induced Ototoxicity and Otoprotection
Evidence of significant hearing loss during the early days of use of cisplatin as a chemotherapeutic agent in cancer patients has stimulated research into the causes and treatment of this side effect. It has generally been accepted that hearing loss is produced by excessive generation of reactive oxygen species (ROS) in cell of the cochlea, which led to the development of various antioxidants a...
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ژورنال
عنوان ژورنال: Practica Oto-Rhino-Laryngologica
سال: 2000
ISSN: 1884-4545,0032-6313
DOI: 10.5631/jibirin.93.533